A healthy lifestyle benefits your brain as much as the rest of your body -- and may lessen the risk of cognitive decline (a loss of the ability to think well) as you age, according to a new advisory from the American Heart Association (AHA) and the American Stroke Association.

Both the heart and brain need adequate blood flow, but in many people, blood vessels slowly become narrowed or blocked over the course of their life, a disease process known as atherosclerosis, the cause of many heart attacks and strokes. Many risk factors for atherosclerosis can be modified by following a healthy diet, getting enough physical activity, avoiding tobacco products and other strategies.

“Research summarized in the advisory convincingly demonstrates that the same risk factors that cause atherosclerosis, are also major contributors to late-life cognitive impairment and Alzheimer’s disease. By following seven simple steps — Life's Simple 7 — not only can we prevent heart attack and stroke, we may also be able to prevent cognitive impairment,” said vascular neurologist Philip Gorelick, M.D., M.P.H., the chair of the advisory’s writing group and executive medical director of Mercy Health Hauenstein Neurosciences in Grand Rapids, Michigan.

Life’s Simple 7 outlines a set of health factors developed by the (AHA) to define and promote cardiovascular wellness. Studies show that these seven factors may also help foster ideal brain health in adults.

The Life’s Simple 7 program urges individuals to:

• Manage blood pressure
• Control cholesterol
• Keep blood sugar normal
• Get physically active
• Eat a healthy diet
• Lose extra weight
• Don’t start smoking or quit

A healthy brain is defined as one that can pay attention, receive and recognize information from our senses; learn and remember; communicate; solve problems and make decisions; support mobility and regulate emotions. Cognitive impairment can affect any or all of those functions.

Start early

The advisory, which is published in the AHA’s journal Stroke, stresses the importance of taking steps to keep your brain healthy as early as possible, because atherosclerosis -- the narrowing of the arteries that causes many heart attacks, heart failure and strokes -- can begin in childhood. “Studies are ongoing to learn how heart-healthy strategies can impact brain health even early in life,” Gorelick said. Although more research is needed, he said, “the outlook is promising.”

Elevations of blood pressure, cholesterol and blood sugar can cause impairment of the large and smaller blood vessels, launching a cascade of complications that reduce brain blood flow. For example, high blood pressure — which affects about 1 in 3 U.S. adults — is known to damage blood vessels that supply oxygen and nutrients to the heart and the brain, Gorelick noted. The damage can lead to a buildup of fatty deposits, or atherosclerosis as well as associated clotting. This narrows the vessels, can reduce blood flow to the brain, and can cause stroke or “mini-strokes.” The resulting mental decline is called vascular cognitive impairment, or vascular dementia.

Risk factors are shared

Previously, experts believed problems with thinking caused by Alzheimer’s disease and other, similar conditions were entirely separate from stroke, but “over time we have learned that the same risk factors for stroke that are referred to in Life’s Simple 7 are also risk factors for Alzheimer’s disease and possibly for some of the other neurodegenerative disorders,” Gorelick said.

The advisory also recognizes that it is important to follow previously published guidance from the AHA, Institute of Medicine and Alzheimer's Association, which include controlling cardiovascular risks and suggest social engagement and other related strategies for maintaining brain health.

The action items from Life’s Simple 7, which are based on findings from multiple scientific studies, meet three practical rules the panel developed in pinpointing ways to improve brain health — that they could be measured, modified and monitored, Gorelick said. Those three criteria make it possible to translate knowledge into action because healthcare providers can assess Life’s Simple 7 elements -- like blood pressure -- easily; they can encourage proven, health-promoting steps and they can gauge changes over time.

The AHA advisory provides a foundation on which to build a broader definition of brain health that includes other influential factors, Gorelick said, such as the presence of atrial fibrillation, a type of irregular heartbeat that has been linked to cognitive problems; education and literacy; social and economic status; the geographic region where a person lives; other brain diseases and head injuries.

It is also a starting point for expanding research into areas such as whether there might be detectable markers, like genetic or brain imaging findings, that represent a susceptibiity for cardiovascular or brain illness, Gorelick said. “At some point in our lives, a ‘switch’ may be getting ready to ‘flip,’ or activate, that sets us in a future direction whereby we become at-risk for cognitive impairment and dementia.”

The cost of dementia

Dementia is costly to treat. Direct care expenses are higher than for cancer and about the same for heart disease, estimates show. Plus, the value of unpaid caregiving for dementia patients may exceed $200 billion a year.

As lives stretch longer in the U.S. and elsewhere, about 75 million people worldwide could have dementia by 2030, according to the advisory. “Policy makers will need to allocate healthcare resources for this,” Gorelick said. Monitoring rates of dementia in places where public health efforts are improving heart health “could provide important information about the success of such an approach and the future need for healthcare resources for the elderly,” he said.

The authors of the advisory reviewed 182 published scientific studies to formulate their conclusions that following Life’s Simple 7 has the potential to help people maintain a healthy brain throughout life.

Co-authors are Karen L. Furie, M.D., M.P.H. (co-chair); Costantino Iadecola, M.D. (co-chair); Eric E. Smith, M.D., M.P.H.; Salina P. Waddy, M.D.; Donald M. Lloyd-Jones, M.D., Sc.M.; Hee-Joon Bae, M.D., Ph.D.; Mary Ann Bauman, M.D.; Martin Dichgans, M.D.; Pamela W. Duncan, Ph.D.; Meighan Girgus, M.B.A.; Virginia J. Howard, Ph.D.; Ronald M. Lazar, Ph.D.; Sudha Seshadri, M.D.; Fernando D. Testai, M.D., Ph.D., M.S.; Stephen van Gaal, M.D.; Kristine Yaffe, M.D.; Hank Wasiak, M.B.A.; and Charlotte Zerna, M.D., M.Sc., on behalf of the American Heart Association/American Stroke Association. Author disclosures are on the manuscript.